Neuroinflammatory Inhibitor MW151

Preferred Label : Neuroinflammatory Inhibitor MW151;

NCIt synonyms : 2-(4-(4-Methyl-6-phenylpyridazin-3-yl)piperazin-1-yl)pyrimidine; Anti-neuroinflammatory Agent MW151; Minozac Free Base;

NCIt definition : An orally bioavailable central nervous system (CNS)-penetrant and inhibitor of certain inflammatory mediators, with potential neuroinflammation attenuating and neuroprotective activities. Upon oral administration, MW151 is able to penetrate the blood-brain-barrier (BBB) and inhibits the up-regulation of certain neuroinflammatory responses upon brain injury or caused by certain diseases. MW151 suppresses neuroinflammation-induced glial activation and prevents the production of certain pro-inflammatory cytokines, such as interleukin-1 beta (IL-1b) and tumor necrosis factor alpha (TNFa). By preventing the overproduction of inflammatory cytokines, over-activated neuroinflammatory pathways are attenuated and associative damage is decreased. This may slow down or prevent certain neurodegenerative disease and cognitive impairment. MW151 may also prevent damage to synapses and synaptic plasticity.;

UNII : FLX2OWQ78O;

CAS number : 886208-65-7;

Molecule name : MW 151; MW01-2-151SRM; MW-151;

NCI Metathesaurus CUI : CL1793641;

Details

Origin ID

C188380;

UMLS CUI

C3501755;

Automatic exact mappings (from CISMeF team)
- 2-(4-(4-methyl-6-phenylpyridazin-3-yl)piperazin-1-yl)pyrimidine [MeSH Supplementary Concept]
- 2-(4-(4-methyl-6-phenylpyridazin-3-yl)piperazin-1-yl)pyrimidine [MeSH concept]
Currated CISMeF NLP mapping
- MW-151 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- MW-151 [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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