NCIt definition : A human immunoglobulin G1 (IgG1) monoclonal antibody targeting certain specific proteins
of the human signal-regulatory protein (SIRP) family, with potential immunoregulatory
activity. Upon administration, anti-SIRP monoclonal antibody ELA026 targets and binds
to SIRP, a cell surface protein expressed on myeloids and T-lymphocytes. This depletes
pathological myeloids and T-lymphocytes that are circulating due to excessive immune
activation and inflammation. This eradicates pathological immune cells that are driving
inflammation. SIRP is a family of cell surface receptors expressed on various immune
cell types. ELA026 does not inhibit the activity of the SIRPalpha/CD47 immune checkpoint.;
Semantic type(s)