Preferred Label : Lutetium Lu 177-EB-LM3;
NCIt synonyms : 177Lu-Evans Blue-modified LM3; 177Lu-EB-LM3;
NCIt definition : A radioconjugate composed of LM3, a human somatostatin receptor (SSTR) antagonist,
conjugated to the albumin-binding dye Evans blue (EB) and linked to the beta-emitting
radioisotope lutetium Lu 177 (177Lu), with potential antineoplastic activity against
SSTR-expressing tumor cells. Upon administration, lutetium Lu 177-EB-LM3 targets and
binds to SSTRs that are present on the cell membranes of many types of neuroendocrine
tumors (NETs). Upon binding, SSTR-expressing tumor cells are destroyed by 177Lu through
the specific delivery of beta particle radiation. This agent also binds to serum albumin
with its EB moiety which increases this agent's half-life and decreases its rate of
clearance. SSTRs have been shown to be present in large numbers on NETs and their
metastases, while most other normal tissues express low levels of SSTRs.;
NCI Metathesaurus CUI : CL1793636;
Origin ID : C188378;
UMLS CUI : C5707732;
Semantic type(s)
- concept_is_in_subset
- has_target
