Preferred Label : MCPyV-LT-encoding Plasmid DNA Vaccine ITI-3000;
NCIt synonyms : pDNA Vaccine ITI-3000; MCPyV-targeted Plasmid DNA Vaccine ITI-3000; L-H LT S220A; Plasmid DNA Vaccine ITI-3000;
NCIt definition : A cancer vaccine consisting of plasmid DNA encoding LTS220A, a truncated form of the
large T antigen (LT) of Merkel cell polyomavirus (MCPyV; MCV) viral oncoprotein with
a detoxifying serine to alanine mutation at position 220, and fused to the lysosome-associated
membrane protein 1 (LAMP1), with potential immunostimulating and antineoplastic activities.
Upon intramuscular administration, the MCPyV-LT-encoding plasmid DNA vaccine ITI-3000
expresses MCPyV-LT, which may elicit cytotoxic T-lymphocyte (CTL) and CD4 T-cell
responses against tumor cells that are expressing MCPyV, resulting in tumor cell lysis.
The MCPyV viral oncoprotein is highly expressed in Merkel cell carcinoma (MCC) caused
by MCPyV infection. Fusion of MCPyV-LT with LAMP1 allows for lysosomal targeting resulting
in enhanced antigen presentation, thereby promoting CD4-positive T-cell responses
and leading to a more balanced immune response.;
Molecule name : ITI-3000; ITI 3000;
NCI Metathesaurus CUI : CL1793610;
Origin ID : C188354;
UMLS CUI : C5706487;
Semantic type(s)
- concept_is_in_subset
- has_target
