Preferred Label : Lead Pb 212 DOTAMTATE;
NCIt synonyms : Pb212-DOTAMTATE; 212Pb-DOTAMTATE;
NCIt definition : A radioconjugate consisting of the tyrosine-containing somatostatin analog Tyr3-octreotate
(TATE) conjugated, through a bifunctional, macrocyclic chelating agent DOTAM (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic
amide; TCMC), to the alpha-emitting radioisotope lead Pb 212, with potential antineoplastic
activity. Upon administration, lead Pb 212 DOTAMTATE targets and binds to somatostatin
receptors (SSTRs) present on the cell membranes of most types of neuroendocrine tumor
(NET) cells. This allows for the specific delivery of a cytotoxic dose of alpha radiation
to SSTR-positive cells. TATE is an octreotide derivative in which phenylalanine at
position 3 is substituted by tyrosine and position 8 threoninol is replaced with threonine.
SSTRs have been shown to be present in large numbers on NET and their metastases,
while most other normal tissues express low levels of SSTRs.;
Drug name : AlphaMedix;
NCI Metathesaurus CUI : CL1793036;
Origin ID : C188306;
UMLS CUI : C5707706;
Semantic type(s)
- concept_is_in_subset
- has_target
