Preferred Label : Vitamin D3 Analogue ILX23-7553;
NCIt synonyms : 1,25-dihydroxy-16-ene-23-yne-cholecalciferol; 16-23-D3; 9,10-Secocholesta-5,7,10(19),16-tetraen-23-yne-1,3,25-triol, (1alpha,3beta,5Z,7E)-;
NCIt related terms : RO-23-7553; ILX23-7553;
NCIt definition : A vitamin D3 analogue with potential antineoplastic activity. ILX23-7553 binds to
and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal
vitamin D responsive tissues, but also overexpressed in certain cancers including
hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor,
this agent induces cancer cell differentiation, inhibits cancer cell growth and induces
apoptosis. In addition, ILX23-7553 may also induce growth arrest and apoptosis independent
of vitamin D receptor activation through mechanisms that are not fully elucidated.;
Alternative definition : NCI-GLOSS: A substance that is being studied as an anticancer drug.;
UNII : O13QTC8612;
InChIKey : JKFZMIQMKFWJAY-RQJQXFIZSA-N;
CAS number : 118694-43-2;
Molecule name : Ro23-7553; ILEX 23-7553; ILX-237553; ILX 237553; RO 237553; BXL 353;
Codes from synonyms : CDR0000044892;
Origin ID : C1883;
UMLS CUI : C0140771;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
