Preferred Label : CMV pp65 Peptide-loaded Alpha-type-1 Polarized Dendritic Cell Vaccine;
NCIt synonyms : Cytomegalovirus pp65 Peptide Loaded Alpha-type 1 Polarized Dendritic Cell Vaccine; CMV pp65 Peptide-loaded Alpha-type-1 Polarized DC Vaccine;
NCIt definition : A dendritic cell (DC)-based cancer vaccine composed of mature polarized DCs (alpha-type-1
polarized DCs) loaded with the human cytomegalovirus (CMV) phosphoprotein pp65 (UL83),
with potential immunostimulatory and antineoplastic activities. Upon administration,
the CMV pp65 peptide-loaded alpha-type-1 polarized DC vaccine exposes the immune system
to the CMV pp65 peptide, which may result in a cytotoxic T-lymphocyte (CTL) response
against CMV pp65-expressing tumor cells leading to tumor cell lysis. The CMV pp65
protein is the primary component of the enveloped subviral particle of CMV and is
expressed in certain tumor types.;
NCI Metathesaurus CUI : CL1793037;
Origin ID : C188291;
UMLS CUI : C5707702;
Semantic type(s)
- concept_is_in_subset
- has_target
