Pelabresib - CISMeF

Preferred Label : Pelabresib;

NCIt synonyms : Pelabresib Monohydrate;

NCIt definition : The hydrated form of pelabresib, a small molecule inhibitor of the Bromodomain and Extra-Terminal (BET) family of proteins, with potential antineoplastic activity. Upon administration, pelabresib binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of two bromodomains at the N-terminus, the BET proteins (BRD2, BRD3, BRD4 and BRDT) are transcriptional regulators that play an important role during development and cellular growth.;

UNII : 306QR91I9R;

CAS number : 1845726-14-8;

Molecule name : CPI-0610;

NCI Metathesaurus CUI : CL1793101;

Details

Origin ID

C188265;

UMLS CUI

C5707688;

Automatic exact mappings (from CISMeF team)
- Pelabresib monohydrate [SMS substance]
Currated CISMeF NLP mapping
- Pelabresib [SMS substance]
Manual BTNT mappings - CISMeF
- pelabresib [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Bromodomain Testis-Specific Protein [NCIt concept]
- Bromodomain-Containing Protein 2 [NCIt concept]
- Bromodomain-Containing Protein 3 [NCIt concept]
- Bromodomain-Containing Protein 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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