Preferred Label : Encequidar Mesylate;
NCIt synonyms : HM30181 Mesylate Monohydrate; 4H-1-Benzopyran-2-Carboxamide, N-(2-(2-(4-(2-(3,4-Dihydro-6,7-Dimethoxy-2(1H)-Isoquinolinyl)ethyl)phenyl)-2H-Tetrazol-5-yl)-4,5-Dimethoxyphenyl)-4-Oxo-,
Methanesulfonate, Hydrate (1:1:1); HM-30181 Methanesulfonate Monohydrate; Encequidar Mesylate Monohydrate;
NCIt definition : The mesylate form of encequidar, an inhibitor of the adenosine triphosphate (ATP)-binding
cassette (ABC) transporter P-glycoprotein (P-gp), with adjuvant activity. Upon oral
administration, encequidar selectively binds to and inhibits the multidrug resistance
(MDR) efflux pump P-gp, which prevents the efflux of various chemotherapeutic agents
from intestinal epithelial cells to the gastrointestinal tract. This leads to an increase
in both oral bioavailability and therapeutic efficacy. P-gp prevents the intestinal
uptake and intracellular accumulation of various cytotoxic agents. Encequidar is not
systemically absorbed.;
UNII : XRZ6538A8R;
CAS number : 2097125-58-9;
Molecule name : HM30181A;
NCI Metathesaurus CUI : CL1793099;
Origin ID : C188262;
UMLS CUI : C5706583;
Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
