Preferred Label : Anti-B7-H3 Antibody-drug Conjugate BAT8009;
NCIt synonyms : Anti-B7-H3 ADC BAT8009; Anti-B7-H3/Exatecan ADC BAT8009; Anti-B7-H3/Exatecan Antibody-drug Conjugate BAT8009;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed
against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) linked to the camptothecin
analog exatecan, with potential antineoplastic activity. Upon administration of anti-B7-H3
ADC BAT8009, the anti-B7-H3 antibody moiety targets and binds to B7-H3-expressing
tumor cells. Upon binding, internalization and linker cleavage, exatecan is released.
Exatecan inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication
and resulting in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation
of B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member
of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell
types and on various immune cells. It is a negative regulator of T-cell activation
and its overexpression plays a key role in tumor cell invasion and metastasis.;
Molecule name : BAT-8009; BAT 8009;
NCI Metathesaurus CUI : CL1793059;
Origin ID : C188243;
UMLS CUI : C5706473;
Semantic type(s)
- concept_is_in_subset
- has_target
