Preferred Label : KRAS G12C Inhibitor D3S-001;
NCIt definition : An orally bioavailable inhibitor of the oncogenic KRAS substitution mutation G12C,
with potential antineoplastic activity. Upon oral administration, KRAS G12C inhibitor
D3S-001 selectively targets the KRAS G12C mutant and inhibits KRAS G12C-mediated signaling.
This may halt proliferation and metastasis in susceptible tumor cells. KRAS, a member
of the RAS family of oncogenes, serves an important role in cell signaling, division
and differentiation. Mutations of KRAS may induce constitutive signal transduction
leading to tumor cell proliferation, invasion, and metastasis.;
Molecule name : D3S 001; D3S-001;
NCI Metathesaurus CUI : CL1793078;
Origin ID : C188231;
UMLS CUI : C5706463;
- Semantic type(s)
- concept_is_in_subset
- has_target