NCIt definition : A bispecific antibody directed against both the T-cell surface antigen CD3 and the
tumor-associated antigen (TAA) CD33, with potential immunostimulating and antineoplastic
activities. Upon administration, anti-CD33/CD3 bispecific antibody binds to both CD3
on cytotoxic T-lymphocytes (CTLs) and CD33 on CD33-expressing tumor cells, thereby
crosslinking tumor cells and CTLs. This activates and redirects CTLs to CD33-expressing
tumor cells, which results in the CTL-mediated cell death of CD33-expressing tumor
cells. CD33, a myeloid differentiation antigen, is expressed on normal non-pluripotent
hematopoietic stem and progenitor cells (HSPCs) and is overexpressed on a variety
of cancer cell types, including acute myeloid leukemia (AML). It plays a key role
in tumor initiation, proliferation and progression.;
Semantic type(s)