Preferred Label : Brivudine Phosphoramidate;
NCIt synonyms : BVDU Prodrug; BVdU Phosphoramidate; (E)-5-(2-Bromovinyl)-2'-deoxy-5'-uridyl Phenyl L-methoxyalaninylphosphoramidate;
NCIt related terms : THYMECTACIN; NB1011;
NCIt definition : A small molecule phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine
(BVdU) with potential antineoplastic activity. Selectively active against tumor cells
expressing high levels of thymidylate synthase (TS), brivudine is converted intracellularly
by TS to bromovinyldeoxyuridine monophosphate (BVdUMP) which competes with the natural
substrate, deoxyuridine monophosphate, for binding to TS. Unlike TS inhibitors, this
agent is a reversible substrate for TS catalysis. Thus, TS retains activity and converts
BVdUMP into cytotoxic metabolites. As key enzyme in the de novo synthesis of dTMP,
TS is an enzyme critical to DNA biosynthesis and is overexpressed in many solid tumors.;
Alternative definition : NCI-GLOSS: A substance that is being studied for its ability to make cancer cells
respond to drugs to which they have become resistant. It is a type of nucleoside analog.;
UNII : 2ZRZ4TSW3F;
CAS number : 232925-18-7;
Drug name : Thymectacin;
Molecule name : NB101.1; NB1011;
Codes from synonyms : CDR0000045075;
Origin ID : C1882;
UMLS CUI : C2830008;
Manual NTBT mappings (CISMeF)
- Semantic type(s)
- concept_is_in_subset
