Preferred Label : BCMA-targeted LCAR-BCDR Cells;
NCIt synonyms : LCAR-BCDR Cells; Anti-BCMA LCAR-BCDR Cells;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) specific for the B-cell maturation antigen (BCMA; tumor necrosis
factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating
and antineoplastic activities. Upon administration, BCMA-targeted LCAR-BCDR cells
specifically recognize and kill BCMA-expressing tumor cells. BCMA, a tumor specific
antigen and a receptor for both a proliferation-inducing ligand (APRIL) and B-cell
activating factor (BAFF), is a member of the tumor necrosis factor (TNF) receptor
superfamily and plays a key role in plasma cell survival; it is found on the surfaces
of plasma cells and overexpressed on malignant plasma cells.;
NCI Metathesaurus CUI : CL1792775;
Origin ID : C188123;
UMLS CUI : C5707600;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
