Preferred Label : ASO-STAT6-loaded PTGFRN-expressing Exosomes CDK-004;
NCIt synonyms : ASO-STAT6 Exosomes; ExoASO-STAT6 CDK-004;
NCIt definition : A preparation of engineered cell-derived exosomes loaded with an antisense oligonucleotide
(ASO) targeting the transcription factor signal transducer and activator of transcription
(STAT) 6 (STAT6) on its surface and expressing high levels of the exosome surface
glycoprotein prostaglandin F2 receptor negative regulator (PTGFRN; CD315), with potential
immunoactivating and antineoplastic activities. Upon intravenous administration, ASO-STAT6-loaded
PTGFRN-expressing exosomes CDK004 preferentially targets and binds to antigen-presenting
cells (APCs), specifically M2 polarized tumor-associated macrophages (TAMs) in the
tumor microenvironment (TME). The selective delivery of ASO STAT6 to the immunosuppressive
TAMs with a M2 phenotype allows for selective reduction of STAT6 mRNA expression in
these cells. By preventing the STAT6 expression in TAMs, the expression of STAT6 target
genes, including the transcription of M2 signature genes, is halted. This increases
the expression of M1 genes and leads to the reprogramming of TAMs toward a pro-inflammatory
M1 phenotype in the TME, and leads to a cytotoxic T-lymphocyte (CTL)-mediated anti-tumor
immune response. This may reduce tumor cell proliferation. STAT6 is a key regulator
of the macrophage M2 transcriptional program and represses the activation of the M1
phenotype.;
Molecule name : CDK 004; CDK-004;
NCI Metathesaurus CUI : CL1792765;
Origin ID : C188120;
UMLS CUI : C5706456;
Semantic type(s)
- concept_is_in_subset
