Preferred Label : Double Recombinant Vaccinia Virus VV-GMCSF-Lact;
NCIt synonyms : VV-GMCSF-Lact;
NCIt definition : A double recombinant oncolytic vaccinia virus (VV; VACV) genetically engineered to
express the human immunostimulatory cytokine granulocyte-macrophage colony-stimulating
factor (GM-CSF), with potential oncolytic, immunostimulating and antineoplastic activities.
The double-recombinant VV-GMCSF-Lact contains deletions of viral thymidine kinase
(TK) and growth factor (GF) gene fragments in the regions of which the genes of GM-CSF
and the oncotoxic protein lactaptin are inserted, respectively. Upon intra-tumoral
administration, the double recombinant vaccinia virus VV-GMCSF-Lact specifically infects
and replicates in tumor cells causing viral-mediated tumor cell lysis. The released
virus particles, in turn, infect and replicate in neighboring tumor cells. Tumor antigens
released from the lysed tumor cells also activate the immune system to induce a tumor-specific
systemic immune and cytotoxic T-lymphocyte (CTL) response, thereby killing nearby
non-infected tumor cells. In addition, VV-GMCSF-Lact promotes the secretion of lactaptin
and GM-CSF. Lactaptin is a fragment of human milk kappa-casein (residues 57-134) that
further induces the apoptotic death of cancer cells . GM-CSF secreted by the tumor
cells attracts dendritic cells (DCs) and may further stimulate a CTL-mediated immune
response against tumor cells.;
NCI Metathesaurus CUI : CL1792769;
Origin ID : C188116;
UMLS CUI : C5707598;
Semantic type(s)
- concept_is_in_subset
