Preferred Label : Anti-PVR Monoclonal Antibody NTX-1088;
NCIt synonyms : Anti-poliovirus Receptor Monoclonal Antibody NTX-1088; Anti-CD155 Monoclonal Antibody NTX-1088;
NCIt definition : An immunoglobulin G4 (IgG4) monoclonal antibody targeting the poliovirus receptor
(PVR; CD155; nectin-like protein 5; NECL-5), with potential immune checkpoint inhibitory,
immunostimulatory and antineoplastic activities. Upon administration, anti-PVR monoclonal
antibody NTX-1088 targets and binds to PVR expressed on tumor cells, thereby preventing
its interactions with the human cell surface glycoprotein CD226 (DNAX accessory molecule-1;
DNAM-1), the co-inhibitory molecule and immune checkpoint inhibitor T-cell immunoreceptor
with immunoglobulin (Ig) and immunoreceptor tyrosine-based inhibitory motif (ITIM)
domains (TIGIT) and the negative immunoregulatory human cell surface receptor CD96
(Tactile; T cell activation increased late expression). The binding of NTX-1088 to
CD226 prevents the internalization of CD226 and restores its expression on the surface
of immune cells. This promotes CD226-dependent signaling pathways, which may trigger
the activation of antigen-presenting cells (APCs) and activate T-cells and natural
killer (NK) cells, and result in an enhanced cytotoxic T-lymphocyte (CTL)-mediated
and NK cell-mediated immune response against tumor cells. The binding of NTX-1088
to TIGIT expressed on various immune cells, particularly on tumor-infiltrating lymphocytes
(TILs), prevents the interaction of TIGIT with its ligands and promotes the interaction
of its ligands with the costimulatory receptor CD226 expressed on immune cells. This
leads to CD226 dimerization and further promotes CD226-mediated signaling and anti-tumor
immune responses. The binding of NTX-1088 to CD96 expressed primarily on T-cells and
NK cells prevents its downstream signaling pathways. This may abrogate CD96-mediated
inhibition of T-cell and NK cell effector function and may further restore immune
function and anti-tumor immune responses through the activation of T-cells and NK
cells. PVR, a key regulator of immune activation through multiple mechanisms, is overexpressed
in a variety of tumor cell types while minimally or not expressed in normal tissues.;
Molecule name : NTX 1088; NTX-1088;
NCI Metathesaurus CUI : CL1792812;
Origin ID : C188066;
UMLS CUI : C5706452;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
