Preferred Label : STING Agonist KL340399;
NCIt definition : An agonist of the intracellular innate immune adaptor stimulator of interferon genes
protein (STING; transmembrane protein 173; TMEM173), with potential immunoactivating
and antineoplastic activities. Upon administration, STING agonist KL340399 targets
and binds to STING and activates the STING pathway in immune cells in the tumor microenvironment
(TME). This leads to the production of pro-inflammatory cytokines, including interferons
(IFNs), enhances the cross-presentation of tumor-associated antigens (TAAs) by antigen-presenting
cells (ADCs), including dendritic cells (DCs), and induces a cytotoxic T-lymphocyte
(CTL)-mediated immune response against cancer cells. STING, a transmembrane protein
that activates immune cells in the TME, plays a key role in the activation of the
innate immune system.;
Molecule name : KL 340399; KL-340399;
NCI Metathesaurus CUI : CL1792832;
Origin ID : C188059;
UMLS CUI : C5706451;
Semantic type(s)
- concept_is_in_subset
- has_target
