Preferred Label : Donor TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated Natural Killer
Cells;
NCIt synonyms : Donor TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated NK Cells; TCR AlphaBeta/CD19-depleted Donor Enriched Activated Natural Killer Cells; Allogeneic TCR Alpha/Beta/CD19-depleted Mononuclear Cell-enriched Activated NK Cells; TCR AlphaBeta/CD19-depleted DEA-NK Cells;
NCIt definition : A preparation of donor-derived, haploidentical, cytokine-activated natural killer
(NK) cells enriched with mononuclear cells from haploidentical donor that have been
depleted of T-cell receptor (TCR) alpha and beta (TCRa/b ) as well as CD19-positive
(CD19 ) cells, that may potentially be used for immune reconstitution purposes. Upon
administration, the donor TCR alpha/beta/CD19-depleted mononuclear cell-enriched activated
NK cells may enhance immune reconstitution. The depletion of alpha/beta T-cells, which
are implicated in the adaptive immune response that mediates graft-versus-host disease
(GvHD), may promote rapid and sustained engraftment, immune reconstitution, and may
prevent or reduce the development of GvHD. The depletion of CD19 B-cells may reduce
the risk of Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disorders.;
NCI Metathesaurus CUI : CL1792833;
Origin ID : C188056;
UMLS CUI : C5707550;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
