Preferred Label : Anti-ILT2 Monoclonal Antibody AGEN1571;
NCIt definition : A human immunoglobulin G4 (IgG4) monoclonal antibody directed against the inhibitory
immune checkpoint receptor Ig-like transcript 2 (ILT2; leukocyte immunoglobulin-like
receptor subfamily B member 1; LILRB1; leukocyte immunoglobulin-like receptor 1; LIR1;
monocyte/macrophage immunoglobulin-like receptor 7; MIR-7; CD85j), with potential
immunomodulating and antineoplastic activities. Upon intravenous administration, anti-ILT2
monoclonal antibody AGEN1571 targets and binds to ILT2. This prevents the binding
of ILT2 ligands, including the immunosuppressive MHC molecule HLA class I histocompatibility
antigen, alpha chain G (HLA-G; human leukocyte antigen G), to the ILT2 receptor and
prevents ILT2-mediated signaling. This inhibits ILT2-mediated immune suppression,
thereby promoting both innate and adaptive immune responses and may result in the
activation of anti-tumor immune responses. ILT2, a transmembrane protein and inhibitory
member of the immunoglobulin-like transcript (ILT) family of proteins, is expressed
on both innate and adaptive immune cells. HLA-G, an immune checkpoint normally expressed
at the maternal-fetal interface, is expressed across multiple tumor types and plays
a key role in cancer immune evasion.;
Molecule name : AGEN-1571; AGEN 1571;
NCI Metathesaurus CUI : CL1792900;
Origin ID : C188044;
UMLS CUI : C5706442;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
