Preferred Label : Technetium Tc-99m DARPinG3;
NCIt synonyms : 99mTc-DARPinG3; 99mTc-labeled DARPinG3; 99mTc-DARPin G3;
NCIt definition : A radioconjugate composed of the scaffold protein DARPinG3, labeled with technetium
Tc 99m, with potential imaging activity for human epidermal growth factor receptor
2 (HER2; EGFR2; ErbB2)-expressing tumor cells upon single photon emission computed
tomography (SPECT)/computed tomography (CT). Upon administration of technetium Tc-99m
DARPinG3, the DARPinG3 moiety targets and binds to HER2-expressing tumor cells. Upon
SPECT/CT imaging, HER2-expressing tumor cells can be detected. HER2, a receptor tyrosine
kinase, is mutated in many tumor cell types and plays a key role in tumor cell proliferation
and tumor vascularization.;
NCI Metathesaurus CUI : CL1792902;
Origin ID : C188042;
UMLS CUI : C5707546;
Semantic type(s)
- concept_is_in_subset
