Preferred Label : Carbon C 14 Ibcasertib;
NCIt synonyms : [14C]-Cioroni; [14C]-CS2164; [14C]-Chiauranib; [14C]Chiauranib; Carbon C 14 Chiauranib; 14C-Ibcasertib;
NCIt definition : An orally bioavailable radioconjugate composed of ibcasertib, an orally bioavailable
inhibitor of select serine-threonine kinases including aurora kinase B (aurora B),
vascular endothelial growth factor receptors (VEGFRs), stem cell factor receptor (c-KIT)
and platelet-derived growth factor receptors (PDGFRs), radiolabeled with the radioisotope
carbon C 14, with potential use for evaluating the pharmacokinetic profile of chiauranib.
Upon oral administration of carbon C 14 ibcasertib, ibcasertib targets, binds to and
inhibits the activity of aurora B, VEGFRs, c-kit and PDGFRs, which may result in a
decrease in the proliferation of tumor cells that overexpress these kinases. Labeling
of ibcasertib with the radioactive tracer carbon C 14 allows for the evaluation of
chiauranib's pharmacokinetic profile, including its absorption, distribution, metabolism
and excretion (ADME).;
NCI Metathesaurus CUI : CL1792344;
Origin ID : C187662;
UMLS CUI : C5707275;
Semantic type(s)
- concept_is_in_subset
