Preferred Label : KRAS G12C Inhibitor HS-10370;
NCIt definition : An orally bioavailable small molecule inhibitor of the oncogenic KRAS substitution
mutation, G12C, with potential antineoplastic activity. Upon oral administration,
KRAS G12C inhibitor HS-10370 selectively targets, binds to and inhibits the activity
of the KRAS G12C mutant, thereby inhibiting KRAS G12C mutant-dependent signaling.
KRAS, a member of the RAS family of oncogenes, serves an important role in cell signaling,
division and differentiation. Mutations of KRAS may induce constitutive signal transduction
leading to tumor cell growth, proliferation, invasion, and metastasis.;
Molecule name : HS 10370; HS-10370;
NCI Metathesaurus CUI : CL1792334;
Origin ID : C187660;
UMLS CUI : C5706429;
Semantic type(s)
- concept_is_in_subset
- has_target
