Preferred Label : Allogeneic Gamma-delta T-lymphocytes TCB-008;
NCIt synonyms : Allogeneic Gamma-delta T Lymphocytes TCB-008; Allogeneic Gamma-delta T-cells TCB-008;
NCIt definition : A preparation of ex vivo-expanded, allogeneic T-lymphocytes that express only gamma
chain and delta chain T-cell receptors (TCRs), with potential immunomodulating and
antineoplastic activities. Upon administration of the allogeneic gamma-delta T-lymphocytes
TCB-008, these cells secrete interferon-gamma (IFN-g) and exert direct killing of
tumor cells. In addition, these cells activate the immune system to exert a cytotoxic
T-lymphocyte (CTL) response against tumor cells. Gamma-delta T-lymphocytes play a
key role in the activation of the immune system and do not require major histocompatibility
complex (MHC)-mediated antigen presentation to exert their cytotoxic effect.;
Molecule name : TCB 008; TCB-008;
NCI Metathesaurus CUI : CL1792419;
Origin ID : C187650;
UMLS CUI : C5706419;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
