Preferred Label : Lurtotecan Liposome;
NCIt synonyms : liposomal lurtotecan; liposome, lurtotecan;
NCIt definition : A liposome-encapsulated formulation of lurtotecan with antineoplastic activity. Lurtotecan,
a semisynthetic analogue of camptothecin, selectively stabilizes the topoisomerase
I-DNA covalent complex and forms an enzyme-drug-DNA ternary complex during S phase
of the cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-stranded
DNA breaks. This ultimately results in an inhibition of DNA replication, inducing
double-stranded DNA breakages, obstruction of RNA and protein synthesis and triggering
apoptosis. Furthermore, this agent also stimulates degradation of topoisomerase I,
likely mediated through ubiquitin-proteasomal pathway. Liposomal delivery of lurtotecan
improves its penetration and delivery into tumors while lowering systemic side effects.;
Molecule name : NX211; OSI-211;
Origin ID : C1876;
UMLS CUI : C0796638;
Semantic type(s)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
