Preferred Label : Pipendoxifene;
NCIt synonyms : 2-(4-Hydroxyphenyl)-3-methyl-1-[4-(2-piperidin-1-ylethoxy)benzyl]-1H-indol-5-ol Hydrochloride; ERA 923;
NCIt related terms : ERA-923;
NCIt definition : A nonsteroidal 2-phenyl indole and a selective estrogen receptor modulator (SERM)
with potential antineoplastic activity. Pipendoxifene antagonizes binding of estradiol
to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated gene expression,
interfering with estrogen activity and inhibiting estrogen-stimulated growth in estrogen-dependent
breast cancer. In addition, this agent also exerts intrinsic estrogenic activity depending
on the tissue types.;
Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer. It belongs
to a family of drugs called antiestrogens.;
UNII : TPC5Q8496G;
InChIKey : JICOGKJOQXTAIP-UHFFFAOYSA-N;
CAS number : 198480-55-6;
Molecule name : ERA 923;
Chemical formula : C29H32N2O3;
Codes from synonyms : 50472; CDR0000044982;
Origin ID : C1874;
UMLS CUI : C1948063;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
