Preferred Label : YAP1 or WWTR1 Fusion Gene Positive;
NCIt synonyms : YAP1/TAZ Fusion Gene; YAP1/WWTR1 Fusion Gene Positive; YAP1 or TAZ Fusion Gene Positive; YAP1/TAZ Fusion Gene Positive;
NCIt definition : An indication that fusions involving either the YAP1 gene or the WWTR1 (TAZ) gene
have been detected in a sample.;
NCIt note : The YAP1 and WWTR1 genes both encode transcriptional coactivators that are involved
in the Hippo signaling pathway; a key regulatory pathway for cell growth, tissue homeostasis,
and organ size. Fusions involving these genes lead to dysregulated transcription activation
and cause the aberrant upregulation of the expression of genes that promote cell survival
and proliferation.;
NCI Metathesaurus CUI : CL1792161;
Origin ID : C187362;
UMLS CUI : C5707049;
Semantic type(s)
- concept_is_in_subset
- related_to_genetic_biomarker
