Preferred Label : Personalized Neoantigen Vaccine NECVAX NEO1;
NCIt definition : A personalized, oral Ty21a-based neoantigen vaccine consisting of eukaryotic expression
plasmid encoding patient-specific tumor neoantigens that are immunogenic and unique
to the patient's tumor, with potential immunomodulating and antineoplastic activities.
Upon oral administration of personalized neoantigen vaccine NECVAX NEO1, the patient-specific
neoantigens elicit a specific and potent cytotoxic T-lymphocyte (CTL) response against
tumor cells expressing these neoantigens. Ty21a is a live-attenuated Salmonella typhi
strain oral typhoid vaccine that is modified and used to deliver the neoantigens-encoding
plasmids to the gut-associated lymphoid tissue.;
Molecule name : NECVAX NEO1; NECVAX-NEO1;
NCI Metathesaurus CUI : CL1792155;
Origin ID : C187351;
UMLS CUI : C5706415;
Semantic type(s)
- concept_is_in_subset
