Preferred Label : Anti-EGFR/Anti-B7-H3 CAR-T Cells;
NCIt synonyms : Anti-EGFR/Anti-B7H3 CAR T Cells; EGFR/B7-H3-targeted CAR T Cells; Anti-EGFR/Anti-CD276 CAR T-cells;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) targeting the epidermal growth factor receptor (EGFR) and the
immunoregulatory protein B7-homologue 3 (B7-H3, CD276), with potential immunostimulating
and antineoplastic activities. Upon administration, the anti-EGFR/anti-B7-H3 CAR-T
cells target and bind to EGFR-expressing tumor cells and B7-H3-expressing immune and
tumor cells, thereby inducing selective toxicity in these cells. EGFR, overexpressed
by a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor
angiogenesis and radio- and chemoresistance. B7-H3, a type I transmembrane protein
and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain
tumor cell types and on various immune cells. It is a negative regulator of T-cell
activation and its overexpression plays a key role in tumor cell invasion and metastasis.;
NCI Metathesaurus CUI : CL1792167;
Origin ID : C187337;
UMLS CUI : C5707037;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
