Preferred Label : HSD-1 Inhibitor SPI-62;
NCIt synonyms : 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor SPI-62; PFKFB3 Inhibitor PFK-158;
NCIt definition : An orally bioavailable selective inhibitor of the enzyme 11beta-hydroxysteroid dehydrogenase
type 1 (11b-HSD1; 11bHSD1; HSD11B1; HSD1; HSD-1), with potential protective activity
for disorders of corticosteroid excess. Upon oral administration, HSD-1 inhibitor
SPI-62 selectively binds to and inhibits the activity of HSD-1. This prevents the
conversion of cortisone to the active hormone cortisol and thereby preventing the
activation of the glucocorticoid receptors (GRs). By blocking cortisol production
in metabolic tissues, SPI-62 may inhibit the adverse metabolic effects that are caused
by exogenous administration of glucocorticoids or in disorders in which cortisol is
secreted in excess. HSD-1 is highly expressed in metabolic tissues, such as liver,
skeletal muscle, and adipose tissue. It plays a crucial role in regulating the production
of cortisol to activate the GRs.;
Molecule name : SPI 62; SPI-62;
NCI Metathesaurus CUI : CL1792255;
Origin ID : C187308;
UMLS CUI : C5706395;
Semantic type(s)
- concept_is_in_subset
- has_target
