Preferred Label : STING-dependent Activators-loaded Autologous Leukemic Cells;
NCIt synonyms : STAVs-loaded Autologous Leukemic Cells;
NCIt definition : A preparation of autologous ultraviolet (UV)-irradiated leukemic cells loaded with
STING-dependent activators (STAVs), with potential immunomodulating and antineoplastic
activities. Upon intravenous administration of STAVs-loaded autologous leukemic cells,
the STAVs activates STING-mediated signaling pathways. This activates the immune response
through the activation of certain immune cells, including dendritic cells (DCs), which
induces the expression of cytokines and chemokines, and leads to an antigen-specific
T-cell mediated immune response against the patient's own leukemic cells. STING, a
transmembrane protein that activates immune cells in the tumor microenvironment (TME),
plays a key role in the activation of the innate immune system. By using the patient's
own irradiated cancer cells as antigens, the patient's immune system is exposed to
the entire repertoire of this individual's tumor-associated antigens (TAAs).;
NCI Metathesaurus CUI : CL1792250;
Origin ID : C187299;
UMLS CUI : C5707014;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
