Preferred Label : EGFR Inhibitor ERAS-801;
NCIt definition : An orally bioavailable, central nervous system (CNS) penetrating inhibitor of epidermal
growth factor receptor (EGFR; ErbB1; HER1) amplifications driven by both oncogenic
EGFR variants and wildtype EGFR, with potential antineoplastic activity. Upon oral
administration, EGFR inhibitor ERAS-801 selectively targets, binds to and inhibits
the activity of EGFR. This prevents EGFR-mediated signaling. This may induce cell
death and inhibit tumor growth in EGFR-overexpressing tumor cells. EGFR, a receptor
tyrosine kinase mutated and overexpressed in many tumors, plays a key role in tumor
cell proliferation and tumor vascularization. ERAS-801 is able to penetrate the blood-brain-barrier
(BBB) and may therefore exert its activity against EGFR-driven CNS primary tumors
and CNS metastases.;
Molecule name : ERAS-801; ERAS 801;
NCI Metathesaurus CUI : CL1792264;
Origin ID : C187232;
UMLS CUI : C5706385;
Semantic type(s)
- concept_is_in_subset
- has_target
