Preferred Label : EBP Inhibitor DSP-0390;
NCIt synonyms : Emopamil-binding Protein Inhibitor DSP-0390;
NCIt definition : An orally bioavailable inhibitor of emopamil-binding protein (EBP), with potential
antineoplastic activity. Upon oral administration, EBP inhibitor DSP-0390 targets,
binds to and inhibits the activity of EBP. This inhibits EBP-mediated de novo cholesterol
synthesis. As cholesterol is essential for tumor cell proliferation and survival,
this inhibits tumor cell proliferation. The inhibition of EBP also results in the
accumulation of its substrates zymostenol and zymosterol, and autophagy in tumor cells.
EBP, a non-glycosylated type I integral membrane protein of endoplasmic reticulum,
plays an important role in cholesterol biosynthesis, autophagy and oligodendrocyte
formation, and is overexpressed in certain tumors.;
Molecule name : DSP 0390; DSP-0390;
NCI Metathesaurus CUI : CL1791933;
Origin ID : C187142;
UMLS CUI : C5706380;
Semantic type(s)
- concept_is_in_subset
- has_target
