Preferred Label : Cytotoxic Agent-LAT1 Substrate QBS10072S;
NCIt definition : A blood-brain-barrier (BBB) penetrative agent composed of a cytotoxic chemotherapeutic
domain, tertiary N-bis(2-chloroethyl)amine, linked to the structural features of a
selective large amino acid transporter 1 (LAT1) substrate, with potential antineoplastic
activity. Upon administration of QBS10072S, the LAT1 substrate binds to LAT1 expressed
on the BBB and in LAT1-expressing cancer cells, such as glioblastoma multiforme (GBM).
After entering the brain and binding to LAT1-expressing tumor cells, the cytotoxic
domain in turn binds to DNA, causing cell cycle arrest and induces apoptosis. LAT1
is expressed at much lower levels in normal brain tissue and QBS10072S may therefore
potentially target brain tumors while avoiding uptake by healthy, normal tissue.;
Molecule name : QBS 72S; QBS 10072S; QBS-72S; QBS-10072S;
NCI Metathesaurus CUI : CL1791932;
Origin ID : C187141;
UMLS CUI : C5706379;
Semantic type(s)
- concept_is_in_subset
- has_target
