Preferred Label : Anti-B7-H3 Antibody-drug Conjugate HS-20093;
NCIt synonyms : Anti-B7-H3 ADC HS-20093; Anti-B7H3 ADC HS-20093;
NCIt definition : An antibody-drug conjugate (ADC) composed of a human immunoglobulin (Ig) G1 monoclonal
antibody directed against the T-cell checkpoint ligand B7-homologue 3 (B7-H3, CD276)
linked to an as of yet undefined cytotoxic agent, with potential antineoplastic activity.
Upon administration of anti-B7-H3 ADC HS-20093, the anti-B7-H3 monoclonal antibody
moiety targets and binds to B7-H3 expressed on tumor cells. Upon binding, internalization
and linker cleavage, the cytotoxic agent is release and induces apoptosis specifically
in B7-H3-expressing tumor cells through an as of yet undefined mechanism of action
(MoA). B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory
protein superfamily, is an immunoregulatory protein overexpressed on certain tumor
cell types and on various immune cells. It is a negative regulator of the T-cell activation
and its overexpression plays a key role in tumor cell invasion and metastasis.;
Molecule name : HS 20093; HS-20093;
NCI Metathesaurus CUI : CL1792009;
Origin ID : C187121;
UMLS CUI : C5706368;
Semantic type(s)
- concept_is_in_subset
- has_target
