Preferred Label : Silevertinib;
NCIt synonyms : EGFR Mutant Inhibitor BDTX-15356; EGFR Inhibitor Mutant-selective BDTX-1535; EGFR Inhibitor BDTX-1535; Mutant EGFR Inhibitor BDTX-1535; Mutant-selective EGFR Inhibitor BDTX-1535;
NCIt definition : An orally bioavailable, brain penetrating, mutant-selective, epidermal growth factor
receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration,
silevertinib selectively targets, irreversibly binds to, and inhibits the activity
of various EGFR alterations and mutations, including certain intrinsic and acquired
resistance mutations. This prevents EGFR-mediated signaling in susceptible tumor cells.
This may both induce cell death and inhibit tumor growth in EGFR-overexpressing tumor
cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a
key role in tumor cell proliferation and tumor vascularization.;
UNII : RP9F537KVY;
CAS number : 2607829-38-7;
Molecule name : BDTX 1535; BDTX-1535;
NCI Metathesaurus CUI : CL1792031;
Origin ID : C187115;
UMLS CUI : C5706362;
Semantic type(s)
- concept_is_in_subset
- has_target
