Preferred Label : Mutant-selective EGFR Inhibitor BDTX-1535;
NCIt synonyms : EGFR Mutant Inhibitor BDTX-15356; EGFR Inhibitor Mutant-selective BDTX-1535; EGFR Inhibitor BDTX-1535; Mutant EGFR Inhibitor BDTX-1535;
NCIt definition : An orally bioavailable, brain penetrating, mutant-selective, epidermal growth factor
receptor (EGFR) inhibitor, with potential antineoplastic activity. Upon oral administration,
mutant-selective EGFR inhibitor BDTX-1535 selectively targets, irreversibly binds
to, and inhibits the activity of various EGFR alterations and mutations, including
certain intrinsic and acquired resistance mutations. This prevents EGFR-mediated signaling
in susceptible tumor cells. This may both induce cell death and inhibit tumor growth
in EGFR-overexpressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many
tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.;
Molecule name : BDTX 1535; BDTX-1535;
NCI Metathesaurus CUI : CL1792031;
Origin ID : C187115;
UMLS CUI : C5706362;
Semantic type(s)
- concept_is_in_subset
- has_target
