Preferred Label : Efgitasialase Alfa;
NCIt synonyms : EAGLE Fusion Protein E-602; Bi-Sialidase Fusion Protein E-602;
NCIt definition : A fusion protein composed of two engineered human sialidase molecules fused to an
Fc antibody domain, with potential immunomodulating and antineoplastic activities.
Upon administration, efgitasialase alfa targets and binds to sialoglycans overexpressed
on the cell surface of certain tumor cells and immune cells, such as exhausted T-cells.
This degrades the immunosuppressive sialoglycans and allows for the re-activation
of the immune system, thereby inducing an anti-tumor immune response. Sialidase is
an enzymatic degrader of immunosuppressive sialoglycans. Efgitasialase alfa is based
on the enzyme-antibody glyco-ligand editing (EAGLE) platform. The Fc domain enhances
retention in the tumor, half-life and manufacturability.;
UNII : WT5G35J9KU;
CAS number : 2891502-37-5;
Molecule name : E-602; E 602;
NCI Metathesaurus CUI : CL1792019;
Origin ID : C187111;
UMLS CUI : C5706358;
Semantic type(s)
- concept_is_in_subset
