Preferred Label : Bi-Sialidase Fusion Protein E-602;
NCIt synonyms : EAGLE Fusion Protein E-602;
NCIt definition : A fusion protein composed of two engineered human sialidase molecules fused to an
Fc antibody domain, with potential immunomodulating and antineoplastic activities.
Upon administration, bi-sialidase fusion protein E-602 targets and binds to sialoglycans
overexpressed on the cell surface of certain tumor cells and immune cells, such as
exhausted T-cells. This degrades the immunosuppressive sialoglycans and allows for
the re-activation of the immune system, thereby inducing an anti-tumor immune response.
Sialidase is an enzymatic degrader of immunosuppressive sialoglycans. E-602 is based
on the enzyme-antibody glyco-ligand editing (EAGLE) platform. The Fc domain enhances
retention in the tumor, half-life and manufacturability.;
Molecule name : E-602; E 602;
NCI Metathesaurus CUI : CL1792019;
Origin ID : C187111;
UMLS CUI : C5706358;
Semantic type(s)
- concept_is_in_subset
