Preferred Label : Nasaruplase Gamma;
NCIt synonyms : scuPA LTI-01; Zymogen LTI-01; Recombinant Single-chain Urokinase Plasminogen Activator LTI-01;
NCIt definition : A proenzyme and recombinant form of single-chain human urokinase plasminogen activator
(scuPA), with potential intrapleural fibrinolytic and draining-promoting activities
in certain lung conditions such as complicated parapneumonic pleural effusion (CPE)
and empyema. After intrapleural administration, nasaruplase gamma is converted into
uPA. uPA breaks down the fibrinous adhesions and promotes the draining of pleural
fluid around the lungs in non-draining loculated pleural effusions (LPE). This may
reduce LPE-associated complications, such as pain, shortness of breath, pleural infections,
and sepsis.;
UNII : 66522BCB6P;
CAS number : 2647419-93-8;
Molecule name : LTI-01; LTI 01;
NCI Metathesaurus CUI : CL1791998;
Origin ID : C187085;
UMLS CUI : C5783447;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
