Preferred Label : Oncolytic HSV-1 Expressing IL-12 and IL-15/IL-15-receptor Alpha VG2025;
NCIt synonyms : oHSV-1 Expressing IL-12 and IL-15/IL-15Ra VG2025;
NCIt definition : An oncolytic herpes simplex virus type 1 (oHSV-1) genetically engineered to express
the human immunostimulating cytokine interleukin (IL)-12 and a complex of the immunostimulating
cytokine IL-15 and its receptor alpha unit (IL-15Ra), with potential immunostimulatory
and antineoplastic activities. Upon intratumoral administration, oHSV-1 expressing
IL-12 and IL-15/IL-15Ra VG2025 infects and replicates in tumor cells causing viral-mediated
tumor cell lysis. The released virus particles, in turn, infect and replicate in neighboring
tumor cells. Tumor antigens released from the lysed tumor cells also activate the
immune system to induce a tumor-specific systemic immune and cytotoxic T-lymphocyte
(CTL) response, thereby killing nearby non-infected tumor cells. In addition, oHSV-1
expressing IL-12 and IL-15/IL-15Ra VG2025 promotes the secretion of IL-12 and IL-15/IL-15Ra
complex by the tumor cells locally in the tumor microenvironment (TME). IL-12 promotes
the activation of natural killer (NK) cells, which induces both the secretion of interferon-gamma
and a CTL response against the tumor cells. IL-15 stimulates the proliferation of
NK cells, CTLs and memory T-cells, which induces an anti-tumor immune response. IL-15Ra
complexed with IL-15 increases IL-15 signaling and IL-15 half-life upon expression.
These actions of the cytokines may increase tumor cell killing and decrease tumor
cell proliferation.;
Molecule name : VG-2025; VG 2025;
NCI Metathesaurus CUI : CL1779245;
Origin ID : C187035;
UMLS CUI : C5667096;
Semantic type(s)
- concept_is_in_subset
