Preferred Label : Indium In 111-DOTA-Daratumumab;
NCIt synonyms : [111In]-DOTA-Daratumumab; 111In-DOTA-Daratumumab;
NCIt definition : A radioimmunoconjugate containing daratumumab, a human immunoglobulin G1 kappa (IgG1k)
monoclonal antibody directed against the cell surface glycoprotein CD38, conjugated
to the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic
acid (DOTA), and labeled with the radioisotope indium In 111, with potential use as
an imaging agent. Upon administration, the monoclonal antibody moiety of indium In
111-DOTA-daratumumab specifically targets and binds to cell surface antigen CD38.
Upon binding and gamma scintigraphy, CD38-expressing tumor cells can be visualized,
and the binding and biodistribution of daratumumab can be assessed. CD38, a cell surface
glycoprotein, is expressed on various hematopoietic cells and is overexpressed on
multiple myeloma (MM) cells.;
NCI Metathesaurus CUI : CL1779112;
Origin ID : C186746;
UMLS CUI : C5670731;
Semantic type(s)
- concept_is_in_subset
- has_target
