Preferred Label : Actinium Ac 225-DOTA-Daratumumab;
NCIt synonyms : [225Ac]-DOTA-Daratumumab; 225Ac-DOTA-Daratumumab;
NCIt definition : A radioimmunoconjugate containing daratumumab, a human immunoglobulin G1 kappa (IgG1k)
monoclonal antibody directed against the cell surface glycoprotein CD38, conjugated
to the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic
acid (DOTA), and labeled with the alpha-emitting radioisotope actinium Ac 225, with
potential antineoplastic activity. Upon administration of actinium Ac 225-DOTA-daratumumab,
the monoclonal antibody moiety specifically targets and binds to cell surface antigen
CD38. Upon binding, the radioisotope moiety delivers a cytotoxic dose of alpha radiation
to CD38-expressing tumor cells. CD38, a cell surface glycoprotein, is expressed on
various hematopoietic cells and is overexpressed on multiple myeloma (MM) cells.;
NCI Metathesaurus CUI : CL1779110;
Origin ID : C186744;
UMLS CUI : C5670729;
Semantic type(s)
- concept_is_in_subset
- has_target
