Preferred Label : Ortataxel;
NCIt synonyms : (3aS,4R,5E,7R,8aS,9S,10aR,12aS,12bR,13S,13aS)-7,12a-Bis(acetyloxy)-13-(benzoyloxy)-9-hydroxy-5,8a,14,14-tetramethyl-2,8-dioxo-3a,4,7,8,8a,9,10,10a,12,12a,12b,13-dodecahydro-6,13a-methano-13aH-oxeto(2',3':5',6')benzo(1',2':4,5)cyclodeca(1,2-d)-1,3-dioxol-4-yl(2R,3S)-3-(((1,1-dimethylethoxy)carbonyl)amino)-2-hydroxy-5-methylhexanoate; Orataxel;
NCIt related terms : BAY 59-8862;
NCIt definition : A semisynthetic, second-generation taxane derivative with potential antineoplastic
activity. Ortataxel binds to and stabilizes tubulin molecules, thereby interfering
with the dynamics of microtubule assembly/disassembly. This results in the inhibition
of cell division and cellular proliferation. As it represents a poor substrate for
P-glycoprotein (P-gp), multi-drug resistance protein (MRP-1) and breast cancer resistance
protein (BCRP) mediated efflux, ortataxel modulates multi-drug resistance mechanisms
and may be useful for treating multi-drug resistant tumors that express Pgp, MRP-1
and BCRP.;
Alternative definition : NCI-GLOSS: A substance that is being studied as a treatment for cancer. It belongs
to the family of drugs called taxanes.;
UNII : 8H61Y4E29N;
InChIKey : BWKDAMBGCPRVPI-ZQRPHVBESA-N;
CAS number : 186348-23-2;
Molecule name : Bay 59-8862; SB-T-101131; IDN5109; BAY59-8862;
Codes from synonyms : CDR0000256546;
Origin ID : C1867;
UMLS CUI : C1527103;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
