Preferred Label : Neoantigen mRNA Personalized Cancer Vaccine SW1115C3;
NCIt synonyms : Neoantigen mRNA PCV SW1115C3; Personalized Cancer Vaccine SW1115C3; mRNA-based Personalized Cancer Vaccine SW1115C3; PCV SW1115C3; Neoantigen mRNA Vaccine SW1115C3;
NCIt definition : A personalized cancer vaccine (PCV) consisting of mRNA encoding a patient's tumor-specific
neoantigens, with potential immunomodulatory and antineoplastic activities. The cells
from the patient's tumor are analyzed, and genetic sequencing is used to identify
neoantigens that may elicit the strongest immune response in the patient. The sequences
encoding these neoantigens are transcribed and loaded onto a single mRNA molecule.
Upon administration of neoantigen mRNA PCV SW1115C3, the mRNA is taken up by and translated
into the desired neoantigens in the patient's antigen-presenting cells (APCs), primarily
dendritic cells (DCs), and presented by major histocompatibility complex (MHC) molecules
on the surface of the APCs. This may activate tumor antigen-specific T-cells to kill
cancer cells expressing these neoantigens.;
Molecule name : SW 1115C3; SW-1115C3;
NCI Metathesaurus CUI : CL1779173;
Origin ID : C186672;
UMLS CUI : C5667081;
Semantic type(s)
- concept_is_in_subset
