Preferred Label : Anti-B7-H3 CAR T Cells TAA06;
NCIt synonyms : Anti-CD276 CAR T Cells TAA06; Anti-B7-H3 CAR T-cells TAA06;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3,
CD276), with potential immunostimulating and antineoplastic activities. Upon administration,
anti-B7-H3 CAR T-cells TAA06 target and bind to B7-H3-expressing tumor cells, thereby
inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane
protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed
on certain tumor cell types and on various immune cells. It is a negative regulator
of T-cell activation and its overexpression plays a key role in tumor cell invasion
and metastasis.;
Molecule name : TAA-06; TAA 06;
NCI Metathesaurus CUI : CL1779169;
Origin ID : C186668;
UMLS CUI : C5667077;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
