Preferred Label : Anti-5T4 CAR-NK Cells;
NCIt synonyms : Anti-5T4 CAR Natural Killer Cells; Anti-5T4 CAR-NKs; Anti-5T4 CAR-redirected Natural Killer Cells;
NCIt definition : A preparation of allogeneic natural killer cells (NKs) expressing a chimeric antigen
receptor (CAR) specific for the tumor-associated antigen (TAA) oncofetal trophoblast
glycoprotein (5T4; TPBG; Wnt-activated inhibitory factor 1 or WAIF1), with potential
immunomodulating and antineoplastic activities. Upon transfusion, the anti-5T4 CAR-NK
cells recognize, bind to and induce selective cytotoxicity in 5T4-expressing tumor
cells. 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer
cell types; its expression is correlated with increased invasiveness.;
NCI Metathesaurus CUI : CL1779166;
Origin ID : C186665;
UMLS CUI : C5670695;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
