Preferred Label : Gallium Ga 68-DOTA-siglec-9;
NCIt synonyms : [68Ga]-DOTA-siglec-9; 68Ga-DOTA-siglec-9;
NCIt definition : A radiopharmaceutical composed of the sialic acid binding Ig-like lectin 9 (siglec-9)
linked by the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic
acid (DOTA) to the positron-emitting radionuclide gallium Ga 68, with potential use
in diagnostic imaging upon positron emission tomography (PET). Upon administration
of gallium Ga 68-DOTA-siglec-9, the siglec-9 moiety binds to the ligand vascular adhesion
protein-1 (VAP-1; amine oxidase, copper containing 3; AOC3) in vasculature. VAP-1
is a homodimeric sialylated glycoprotein with enzymatic activity that is expressed
on the endothelium of human tissues such as skin, brain, lung, liver and heart in
both normal and inflammatory conditions; it mediates leukocyte migration from the
bloodstream to sites of inflammation and can also be found in certain cancers. Siglec-9
is primarily expressed on neutrophils, monocytes, macrophages, and dendritic cells.
Detection of siglec-9 binding to VAP-1 using PET may serve as a surrogate marker for
inflammation and the presence of cancer cells.;
NCI Metathesaurus CUI : CL1779158;
Origin ID : C186657;
UMLS CUI : C5670690;
Semantic type(s)
- concept_is_in_subset
- has_target
