Central Nervous System CIC-Rearranged Sarcoma

Preferred Label : Central Nervous System CIC-Rearranged Sarcoma;

NCIt synonyms : CNS CIC-Rearranged Sarcoma;

NCIt definition : A rare, undifferentiated, high grade small round cell sarcoma that arises from the central nervous system. It is characterized by a recurrent translocation involving the CIC gene on chromosome 19 resulting in CIC gene fusion with different gene partners.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1778783;

Details

Origin ID

C186607;

UMLS CUI

C5670657;

Disease excludes normal cell origin
- Epithelial Cell [NCIt concept]
Excludes anatomical site(s)
- Bone [NCIt concept]
- Lung [NCIt concept]
Has associated anatomic sites
- Central Nervous System [NCIt concept]
- Connective and Soft Tissue [NCIt concept]
- Nervous System [NCIt concept]
Has cytogenetic abnormalities
- CIC Gene Rearrangement [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_cytogenetic_abnormality
- EWSR1 Gene Rearrangement [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Intermediate Filaments Present [NCIt concept]
- Intracytoplasmic Eosinophilic Inclusion [NCIt concept]
disease_excludes_normal_tissue_origin
- Epithelial Tissue [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Malignant Small Cell [NCIt concept]
- Malignant Small Round Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
disease_has_finding
- High Grade Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
disease_has_normal_tissue_origin
- Connective and Soft Tissue [NCIt concept]
- Soft Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Central Nervous System [NCIt concept]
disease_mapped_to_gene
- CIC Gene [NCIt concept]

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