Preferred Label : Ribozyme RPI.4610;
NCIt synonyms : Anti-Flt-1 Ribozyme;
NCIt related terms : Angiozyme; RPI.4610;
NCIt definition : A nuclease-stabilized synthetic ribozyme (ribonucleic acid enzyme) with potential
anti-angiogenesis activity. Ribozyme RPI.4610 specifically recognizes the mRNA for
FLT1 (vascular endothelial growth factor receptor 1; VEGFR1), and hydrolyzes the mRNA,
thereby preventing VEGFR1 proteins from being made. This may prevent VEGF-stimulated
angiogenesis in cancerous tissue and metastasis.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. RPI.4610 is a special
type of RNA made in the laboratory. It stops a protein called vascular endothelial
growth factor receptor (VEGFR) from being made. This may prevent the growth of new
blood vessels that tumors need to grow. It is a type of angiogenesis inhibitor and
a type of ribozyme.;
Drug name : Angiozyme;
Molecule name : RPI4610; RPI.4610;
Codes from synonyms : CDR0000045036; CDR0000413942;
Origin ID : C1865;
UMLS CUI : C2980021;
Semantic type(s)
- concept_is_in_subset
