Spinal Cord Ependymoma, MYCN Amplified

Preferred Label : Spinal Cord Ependymoma, MYCN Amplified;

NCIt synonyms : Spinal Ependymoma, MYCN Amplified; Spinal Ependymoma, MYCN-Amplified; Spinal Cord Ependymoma, MYCN-Amplified;

NCIt definition : A rare, aggressive ependymoma that arises from the spinal cord. It displays microvascular proliferation, necrosis, and high mitotic rate. It is characterized by high-level MYCN amplification. Cytogenetic abnormalities include loss of chromosome 10 and focal losses on chromosome 11q. The prognosis is poor.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL1778904;

Détails

Origin ID

C186494;

UMLS CUI

C5670583;

Disease may have findings
- Calcification [NCIt concept]
Has associated anatomic sites
- Central Nervous System [NCIt concept]
- Nervous System [NCIt concept]
- Spinal Cord [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
disease_excludes_finding
- Absence of MYCN Gene Amplification [NCIt concept]
- Anaplastic Lesion [NCIt concept]
- Benign Cellular Infiltrate [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Precise Histogenesis Unknown [NCIt concept]
disease_excludes_molecular_abnormality
- MYCN Gene Amplification [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Ependymal Cell [NCIt concept]
- Neoplastic Glial Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell [NCIt concept]
disease_has_finding
- Absence of MYCN Gene Amplification [NCIt concept]
- Aggressive Clinical Course [NCIt concept]
- High Mitotic Activity [NCIt concept]
- Low Grade Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Microvascular Proliferation [NCIt concept]
- Monomorphic Cellular Infiltrate [NCIt concept]
- Necrotic Change [NCIt concept]
- Slow Growing Mass [NCIt concept]
disease_has_grade
- Grade 2 [NCIt concept]
disease_has_molecular_abnormality
- MYCN Gene Amplification [NCIt concept]
disease_has_normal_cell_origin
- Ependymal Cell [NCIt concept]
- Glial Cell [NCIt concept]
- Neuroepithelial Cell [NCIt concept]
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
disease_has_normal_tissue_origin
- Ependyma and Remnants of the Central Canal of the Spinal Cord [NCIt concept]
- Nerve Tissue, Neuroepithelial Tissue, and Nerve Sheaths [NCIt concept]
- Neuroepithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Central Nervous System [NCIt concept]
- Spinal Cord [NCIt concept]
disease_mapped_to_gene
- NF2 Gene [NCIt concept]
disease_may_have_cytogenetic_abnormality
- Loss of Chromosome 10 [NCIt concept]
- Loss of Chromosome 11q [NCIt concept]
- Loss of Chromosome 22q [NCIt concept]
disease_may_have_molecular_abnormality
- NF2 Gene Mutation [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

Vous pouvez consulter :

recommendations
documents concerning education
documents for patients