Preferred Label : Pegtomarginase;
NCIt definition : A genetically modified form of human enzyme arginase (ARG) site-specifically linked
with a linear 20 kDa polyethylene glycol (PEG), with potential arginine depleting
and antineoplastic activities. Upon intravenous administration of pegtomarginase,
arginase metabolizes the amino acid arginine to ornithine and urea, thereby lowering
blood arginine levels. This normalizes blood arginine levels in patients with arginase
deficiency and prevents hyperargininemia. As many cancer types lack the ability to
synthesize arginine due to deficient expression of certain metabolic enzymes of the
urea cycle and are dependent on extracellular arginine uptake for their proliferation,
depriving cancer cells of arginine inhibits their proliferation. In normal, healthy
cells, arginine is synthesized intracellularly by metabolic enzymes of the urea cycle,
including ornithine transcarbamylase (OTC), argininosuccinate synthase (ASS), and
argininosuccinate lyase (ASL), and they are not dependent on extracellular arginine
for survival. Pegylation improves blood circulation times of this agent.;
Molecule name : PT-01; PT 01; A20CL;
NCI Metathesaurus CUI : CL1778874;
Origin ID : C186490;
UMLS CUI : C5670581;
Semantic type(s)
- concept_is_in_subset
